A recent study suggests that patients who stop using new weight-loss injections like Mounjaro or Wegovy may regain reduced body mass much more quickly than those who stop traditional diet and exercise regimens.
Findings released in a leading medical journal points out that while obese people frequently drop substantial amounts of their body weight while using the jabs, the weight is regained at an average rate of nearly a kilo each month upon discontinuation.
"Users purchasing such drugs must be informed of the danger of fast rebound weight gain when the medication is stopped," stated researcher Dr. Susan Jebb.
This pace of recovery means a return to starting mass within about 18 months.
Weighing Therapies
The research, which reviewed dozens of trials involving over 9,000 of patients, contrasted the results of these new drugs with conventional dieting.
Scientists emphasize that individuals who shed pounds through diet and exercise generally see a more gradual weight regain—perhaps 100 grams monthly—once they finish.
Explaining the Quick Regain
Experts suggest the mechanism of the injections is key to understanding the heightened weight return.
The injections copy a natural hormone called GLP-1, which moderates hunger.
"Long-term administration of GLP-1 levels several times higher than normal could lead to the system to produce less of its endogenous hormone, and could reduce responsiveness to its actions," said Dr. Adam Collins, a dietetics researcher.
"Stopping of this medication leads to appetite is no longer kept in check, making binge eating far more likely."
An Ongoing Disease?
The NHS advise the injections for people with obesity-related medical conditions, alongside prescribed diet and exercise modifications.
Professionals say that, due to the likelihood of relapse, the treatment might need to be ongoing.
This view is supported by drug manufacturers, who say that the findings "emphasize the persistent nature of excess weight," akin to managing conditions like high blood pressure.
Patient Accounts
Users who have come off the jabs explain a sudden return of cravings.
"I experienced a trigger that goes on and you're instantly extremely hungry," said one woman.
The struggle is compounded if patients have not adopted permanent dietary or behavioural changes during treatment.
Growing Interest
Figures indicate that a significant number of adults in the UK have tried these injections in the last 12 months, with desire continuing to grow.
- Use is higher among females than males.
- The middle-aged age group shows the greatest level of interest.
- A large proportion access the medications through private prescriptions rather than the NHS.
In conclusion, experts emphasize that while these medications are effective tools for weight loss, they are not a permanent cure and long-term success likely depends on ongoing behavioural changes.
